Abiding by the COVID-19 protocols has made obtaining handwritten “wet ink” signatures whether face-to-face or by scanning copies of signed documents for business transactions more difficult. This article examines the existing legal framework in Ghana in the light of the impact of these COVID-19 restrictions on business transactions, in particular, the inability to execute material contracts and other documents with handwritten “wet ink” signatures and the use of e-signature in contracts generally. It must be noted that e-signatures are increasingly being adopted for various business transactions to enable the easy signing of contracts, agreements, and partnerships among others in both in-country and cross-border transactions.